Apoptosis meets necrosis

Apoptosis More than Meets the Eye

the evolutionary patterns we are learning to discern in et al.) and in Drosophila (M. Labrador and V. Corces). whole genome sequences. When Mobile DNA III comes We need to learn more about how these connections out in the next decade of this century, we can look form the molecular basis for the regulated timing and forward not only to learning more about the mechanics specificity of retrotransp...

Apoptosis versus necrosis in acute pancreatitis.

Acute pancreatitis is a disease of variable severity in which some patients experience mild, self-limited attacks, whereas others manifest a severe, highly morbid, and frequently lethal attack. The events that regulate the severity of acute pancreatitis are, for the most part, unknown. It is generally believed that the earliest events in acute pancreatitis occur within acinar cells and result i...

Programmed necrosis, not apoptosis, in the heart.

It is well known that apoptosis is an actively mediated cell suicide process. In contrast, necrosis, a morphologically distinct form of cell death, has traditionally been regarded as passive and unregulated. Over the past decade, however, experiments in Caenorhabditis elegans and mammalian cells have revealed that a significant proportion of necrotic death is, in fact, actively mediated by the ...

Necrosis and apoptosis in the gastrointestinal tract.

Tumor Necrosis Factor An Apoptosis JuNKie?

TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far a...